Lipid-like behavior of signal sequence peptides at air–water interface
نویسندگان
چکیده
منابع مشابه
Salts drive controllable multilayered upright assembly of amyloid-like peptides at mica/water interface.
Surface-assisted self-assembly of amyloid-like peptides has received considerable interest in both amyloidosis research and nanotechnology in recent years. Despite extensive studies, some controlling factors, such as salts, are still not well understood, even though it is known that some salts can promote peptide self-assemblies through the so-called "salting-out" effect. However, they are usua...
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Signal peptides (SP) are responsible for the secretion of mature proteins, and signal-anchor sequences of type I and type II (SA-1, SA-2) translocate C-terminal and N-terminal segments, respectively [1]. However, it is difficult to discriminate difference between SP and SA-2 from the information of amino acid sequences alone, because the difference between those sequences does not have signific...
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The eukaryotic signal recognition particle (SRP) is essential for cotranslational targeting of proteins to the endoplasmic reticulum (ER). The SRP Alu domain is specifically required for delaying nascent chain elongation upon signal sequence recognition by SRP and was therefore proposed to interact directly with ribosomes. Using protein cross-linking, we provide experimental evidence that the A...
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We have systematically analyzed the molecular environment of the signal sequence of a growing secretory protein from Escherichia coli using a stage- and site-specific cross-linking approach. Immediately after emerging from the ribosome, the signal sequence of pOmpA is accessible to Ffh, the protein component of the bacterial signal recognition particle, and to SecA, but it remains attached to t...
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Self-assembling amphiphilic designer peptides have been successfully applied as nanomaterials in biomedical applications. Understanding molecular interactions at the peptide-membrane interface is crucial, since interactions at this site often determine (in)compatibility. The present study aims to elucidate how model membrane systems of different complexity (in particular single-component phosph...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2013
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2012.11.004